3-broMo-5-iodo-phenol

Base Information

• Chemical Name: 3-broMo-5-iodo-phenol
• CAS No.: 570391-20-7
• Molecular Formula: C6H4BrIO
• Molecular Weight: 298.906
• Hs Code.: 2908199090
• Mol file: 570391-20-7.mol

Synonyms:3-bromo-5-iodo-phenol;3-Brom-5-jod-phenol;

Chemical Property of 3-broMo-5-iodo-phenol

Chemical Property:

• PSA: 20.23000
• LogP: 2.75930
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99.00% ^*data from raw suppliers

3-Bromo-5-iodophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Bromo-5-iodophenol is a reactant in the preparation of N-[3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl]methanesulfonamide (LP-261), a potent antimitotic agent.

Technology Process of 3-broMo-5-iodo-phenol

There total 9 articles about 3-broMo-5-iodo-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromo-3-iodo-5-methoxybenzene (915412-18-9) → 3-bromo-5-iodophenol (570391-20-7)

Guidance literature:

With hydrogen bromide; acetic acid; tetrabutylammomium bromide; for 48h; Heating / reflux;

Reference yield: 86.0%

3-(3-bromo-5-iodophenyl)-1,1,1,3,5,5,5-heptamethyltrisiloxane → 3-bromo-5-iodophenol (570391-20-7)

Guidance literature:

With potassium hydrogen difluoride; dihydrogen peroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere; Glovebox;

DOI:10.1021/ja511352u

Reference yield: 86.0%

→ 3-bromo-5-iodophenol (570391-20-7)

Guidance literature:

With potassium hydrogen difluoride; dihydrogen peroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

1-Bromo-3-iodobenzene

1-bromo-3-iodo-5-methoxybenzene

3,5-dibromonitrobenzene

2,6-dibromo-4-nitroaniline

Downstream raw materials:

4-(3-(4-methoxybenzyloxy)-5-(pyridin-3-yl)phenyl)-1-(triisopropylsilyl)-1H-indole

(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanol

4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

3-(hydroxy(pyridin-3-yl)methyl)-5-(1H-indol-4-yl)phenol

Refernces

• 1、 -. "INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES". Paragraph 00184-00185. . Retrieved 2015/03/28.
• 2、 -. "ANTI-CANCER AGENTS ANS USES THEREOF". Page/Page column 117. . Retrieved 2010/11/29.