3-Furylpyridine

Base Information

• Chemical Name: 3-Furylpyridine
• CAS No.: 55484-05-4
• Molecular Formula: C9H7NO
• Molecular Weight: 145.161
• DSSTox Substance ID: DTXSID30903070
• Nikkaji Number: J915.870G
• Mol file: 55484-05-4.mol

Synonyms:3-furylpyridine;NoName_3658;2-(furan-3-yl)pyridine;SCHEMBL2099096;DTXSID30903070;55484-05-4

Chemical Property of 3-Furylpyridine

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 145.052763847
• Heavy Atom Count: 11
• Complexity: 127

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=COC=C2

Technology Process of 3-Furylpyridine

There total 1 articles about 3-Furylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

furan (110-00-9) + N-fluoropyridinium triflate (107263-95-6) → pyridin-2-yl trifluoromethanesulfonate (65007-00-3) + 2-fluoropyridine (372-48-5) + 2-(furan-3’-yl)pyridine (55484-05-4) + 2-(2'-furyl)pyridine (55484-03-2)

Guidance literature:

With triethylamine; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96186-0

Reference yield: 50.0%

ortho-methylphenyl iodide (615-37-2) + carbon monoxide (201230-82-2) + 2-(furan-3’-yl)pyridine (55484-05-4) → (3-(pyridin-2'-yl)furan-2-yl)(o-tolyl)methanone

Guidance literature:

With benzoxazole; (η4-1,5-cyclooctadiene)dichlororuthenium(II); potassium acetate; sodium hydrogencarbonate; In water; at 120 ℃; for 20h; under 22502.3 Torr; Autoclave; Inert atmosphere;

DOI:10.1002/anie.201301663

Reference yield: 26.0%

2-(furan-3’-yl)pyridine (55484-05-4) + benzaldehyde (100-52-7) → phenyl[3-(pyridin-2-yl)furan-2-yl]methanone

Guidance literature:

With tert.-butylhydroperoxide; palladium diacetate; Trimethylacetic acid; In decane; 1,2-dichloro-ethane; at 80 ℃; for 0.25h; regioselective reaction; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1039/d1ob02176a

upstream raw materials:

furan

N-fluoropyridinium triflate

Refernces

• 1、 Unemoto, Teruo,Tomizawa, Ginjiro. "BASE-INITIATED REACTIONS OF N-FLUOROPYRIDINIUM SALTS; A NOVEL CYCLIC CARBENE PROPOSED AS A REACTIVE SPECIES". . p. 2705 - 2708. Retrieved 2007/10/02.