Benzylhydrazine hydrochloride

Base Information

• Chemical Name: Benzylhydrazine hydrochloride
• CAS No.: 20570-96-1
• Molecular Formula: C7H10N2^.2(HCl)
• Molecular Weight: 195.092
• Hs Code.: 29280000
• European Community (EC) Number: 677-991-7
• NSC Number: 25734
• DSSTox Substance ID: DTXSID90147998
• ChEMBL ID: CHEMBL1434568
• Mol file: 20570-96-1.mol

Synonyms:benzylhydrazine;benzylhydrazine dihydrochloride;benzylhydrazine monohydrochloride

Chemical Property of Benzylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: slightly yellow to beige powder
• Melting Point: 143-145 °C (dec.)(lit.)
• Boiling Point: 265.4 °C at 760 mmHg
• Flash Point: 132 °C
• PSA: 38.05000
• Density: 1.033g/cm3
• LogP: 3.34510
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Insoluble in water.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 158.0610761
• Heavy Atom Count: 10
• Complexity: 67.3

Purity/Quality:

99% ^*data from raw suppliers

Benzylhydrazine DiHcl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNN.Cl
• Uses: Benzylhydrazine dihydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Technology Process of Benzylhydrazine hydrochloride

There total 13 articles about Benzylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-benzyl-N’-[(tert-butoxy)carbonyl](tert-butoxy)carbohydrazide (185456-43-3) → N-benzylhydrazine hydrochloride (1073-62-7,20570-96-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/S0960-894X(01)00549-2

Reference yield: 78.0%

2-(benzylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + benzylhydrazine dihydrochloride (20570-96-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

Reference yield:

N-benzyl-N'-isopropylidene-hydrazinecarboxylic acid tert-butyl ester (561067-10-5) → benzylhydrazine dihydrochloride (20570-96-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1055/s-2004-831336

upstream raw materials:

N'-benzylhydrazinecarboxylic acid tert-butyl ester

benzaldehyde benzylhydrazone

tert-butyl 1-benzylhydrazine-1-carboxylate

N-benzyl-N’-[(tert-butoxy)carbonyl](tert-butoxy)carbohydrazide

Downstream raw materials:

2-benzylthiosemicarbazide

N₂-benzyl thiosemicarbazide

1-Ethansulfonyl-1-benzyl-2-benzyliden-hydrazin

6-(1-benzylhydrazino)-4(3H)-pyrimidinone

Refernces

• 1、 Yatham, Veera Reddy,Bellotti, Peter,K?nig, Burkhard. "Decarboxylative hydrazination of unactivated carboxylic acids by cerium photocatalysis". supporting information. p. 3489 - 3492. Retrieved 2019/03/26.
• 2、 Ling, Lei,Urichuk, Liana J.,Sloley,Coutts, Ronald T.,Baker, Glen B.,Shan, Jacqueline J.,Pang, Peter K.T.. "Synthesis of N-propargylphenelzine and analogues as neuroprotective agents". . p. 2715 - 2717. Retrieved 2007/10/03.