SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE

Base Information

• Chemical Name: SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
• CAS No.: 1184-16-3
• Molecular Formula: C21H28N7O17P3.Na
• Molecular Weight: 765.393
• Hs Code.: 29349990
• Mol file: 1184-16-3.mol

Synonyms:beta-NADP-sodium salt;SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;UNII-NR2O7P57YA;NR2O7P57YA;EINECS 214-664-6;NSC 20273;Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate),5',5'-ester with 3-(aminocarbonyl)-1-beta-d-ribofuranosylpyridini um hydroxide, inner salt, monosodium salt;SPECTRUM1503902;HMS502D08;HMS1922I22;CCG-39055;cofactor in aryl and steroidal hydroxylation

Chemical Property of SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE

Chemical Property:

• Appearance/Colour: off-white to yellow powder
• Melting Point: 175-178 °C
• PSA: 399.88000
• LogP: -0.74100
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 21
• Rotatable Bond Count: 13
• Exact Mass: 765.05739769
• Heavy Atom Count: 49
• Complexity: 1290

Purity/Quality:

99%,95%, ^*data from raw suppliers

β-Nicotinamide Adenine Dinucleotide Phosphate, Sodium Salt Hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): XnXi
• Hazard Codes: Xn,Xi
• Statements: 36-36/37/38
• Safety Statements: 22-24/25-37/39-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)[O-])O)O)O)C(=O)N.[Na+]
• Isomeric SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)[O-])O)O)O)C(=O)N.[Na+]
• Uses: β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes. β-Nicotinamide adenine dinucleotide phosphate monosodium salt acts as an electron acceptor used by cells. It is also useful in vitro to study NADP. Furthermore, it is used in a wide range of enzyme catalyzed oxidation reduction reactions. The combination of NADP+/NADPH is employed in a variety of antioxidation mechanisms, which protect against reactive oxidation species accumulation.

Technology Process of SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE

There total 1 articles about SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium β-nicotinamide adenine dinucleotide phosphate → β-nicotinamide adenine dinucleotide phosphate sodium salt (1184-16-3)

Guidance literature:

With metaphosphate; In water; at 37 ℃; for 2h; enzyme from Brevibacterium ammoniagenes, MgCl₂, (Tris)-HCl buffer (pH 7.0);

Reference yield: 92.0%

β-nicotinamide adenine dinucleotide phosphate sodium salt (1184-16-3) → <4-2H1>NADP

Guidance literature:

With cyanide^(1-); deuterium;

DOI:10.1039/c39910000976

Reference yield: 51.0%

5-thiomethyl nicotinic acid (74470-28-3) + β-nicotinamide adenine dinucleotide phosphate sodium salt (1184-16-3) → 1-[(2R,3R,4S,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxyhydroxyphosphoryl]oxyhydroxyphosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]pyridin-1-ium-5-thiomethyl-3-carboxylic acid

Guidance literature:

5-thiomethyl nicotinic acid; With sodium hydroxide; In water; dimethyl sulfoxide; at 37 ℃; for 1h; pH=4; Inert atmosphere;

β-nicotinamide adenine dinucleotide phosphate sodium salt; In water; dimethyl sulfoxide; for 0.0833333h; pH=4; Inert atmosphere;

With Aplysia californica ADP-ribosyl cyclase; In water; dimethyl sulfoxide; at 37 ℃; for 2h; pH=4; Inert atmosphere; Enzymatic reaction;

DOI:10.1021/acs.jmedchem.5b00279

Refernces