N-METHYL 3-NITROBENZENESULFONAMIDE

Base Information

• Chemical Name: N-METHYL 3-NITROBENZENESULFONAMIDE
• CAS No.: 58955-78-5
• Molecular Formula: C7H8N2O4S
• Molecular Weight: 216.218
• Hs Code.: 2935009090
• Mol file: 58955-78-5.mol

Synonyms:N-Methyl-3-nitrobenzenesulfonamide;

Chemical Property of N-METHYL 3-NITROBENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 1.19E-05mmHg at 25°C
• Melting Point: 110-114 °C
• Refractive Index: 1.57
• Boiling Point: 369.4 °C at 760 mmHg
• PKA: 10.41±0.30(Predicted)
• Flash Point: 177.2 °C
• PSA: 100.37000
• Density: 1.423 g/cm³
• LogP: 2.49780
• Storage Temp.: Keep Cold

Purity/Quality:

98%Min ^*data from raw suppliers

N-Methyl-3-nitrobenzenesulfonamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYL 3-NITROBENZENESULFONAMIDE

There total 4 articles about N-METHYL 3-NITROBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methylamine (74-89-5) + 3-nitrobenzenesulphonyl chloride (121-51-7) → N-methyl-3-nitrobenzenesulfonamide (58955-78-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 0.25h;

DOI:10.1002/ejoc.201501032

Reference yield: 82.0%

methylamine hydrochloride salt + 3-nitrobenzenesulphonyl chloride (121-51-7) → N-methyl-3-nitrobenzenesulfonamide (58955-78-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

3-nitro-benzenesulfonic acid-(methyl-nitro-amide) (59263-05-7) → methanol (67-56-1) + N-methyl-3-nitrobenzenesulfonamide (58955-78-5) + 3-Nitrobenzenesulfonic acid (98-47-5)

Guidance literature:

With sulfuric acid; In water; at 25 ℃; Rate constant; Dependence of the decomposition rate on concentration of H₂SO₄;

upstream raw materials:

methylamine

3-nitrobenzenesulphonyl chloride

3-nitro-benzenesulfonic acid-(methyl-nitro-amide)

Downstream raw materials:

3-amino-N-methylbenzenesulfonamide

N-(5-chloro-2-phenyl-4H-1,3-oxazin-6-yl)-N-methyl-3-nitrobenzenesulfonamide

3-nitro-benzenesulfonic acid-(methyl-nitro-amide)

3-nitro-benzenesulfonic acid-(N-methyl-2,4-dinitro-anilide)

Refernces

• 1、 Al-Sanea, Mohammad M.,Elkamhawy, Ahmed,Paik, Sora,Bua, Silvia,Ha Lee, So,Abdelgawad, Mohamed A.,Roh, Eun Joo,Eldehna, Wagdy M.,Supuran, Claudiu T.. "Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamidesAQ3 as carbonic anhydrase isoforms I and II inhibitors". . p. 1457 - 1464. Retrieved 2019/08/26.
• 2、 -. "METHODS FOR INHIBITING NECROPTOSIS". Page/Page column 81. . Retrieved 2015/12/30.