3,5-Difluorobenzyl alcohol

Base Information

• Chemical Name: 3,5-Difluorobenzyl alcohol
• CAS No.: 79538-20-8
• Molecular Formula: C7H6F2O
• Molecular Weight: 144.121
• Hs Code.: 29062990
• Mol file: 79538-20-8.mol

Synonyms:(3,5-Difluorophenyl)methanol;

Chemical Property of 3,5-Difluorobenzyl alcohol

Chemical Property:

• Appearance/Colour: clear colorless to very slightly brown liquid
• Vapor Pressure: 0.539mmHg at 25°C
• Refractive Index: n20/D 1.487(lit.)
• Boiling Point: 182 °C at 760 mmHg
• PKA: 13.75±0.10(Predicted)
• Flash Point: 94.4 °C
• PSA: 20.23000
• Density: 1.29 g/cm³
• LogP: 1.45710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,5-Difluorobenzyl Alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3,5-Difluorobenzyl alcohol is used as pharmaceutical intermediate.

Technology Process of 3,5-Difluorobenzyl alcohol

There total 1 articles about 3,5-Difluorobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluorobenzaldehyde (32085-88-4) → 3,5-difluorobenzyl alcohol (79538-20-8)

Guidance literature:

With sodium borohydrid; In ethanol;

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + 3,5-difluorobenzyl alcohol (79538-20-8) → (3,5-difluorophenyl)methyl methanesulfonate

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield: 99.0%

ethyl iodide (75-03-6) + 3,5-difluorobenzyl alcohol (79538-20-8) → 1-(ethoxymethyl)-3,5-difluorobenzene (1572403-26-9)

Guidance literature:

3,5-difluorobenzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

ethyl iodide; In N,N-dimethyl-formamide; for 18h; Cooling with ice;

upstream raw materials:

3,5-difluorobenzaldehyde

Downstream raw materials:

3,5-difluorobenzaldehyde

(3,5-difluorobenzyl) 2,2,2-trichloroacetimidate

[4-(3,7-dimethylocta-2,6-dienyl)-3,5-difluorobenzyl]phosphonic acid diethyl ester

Refernces

• 1、 -. "Fluorine-substituted-4-alkenylbenzoic acid and derivatives thereof, and nematic liquid crystal composition containing cyanophenyl benzoate derivatives and liquid crystal display system using the same". . . Retrieved 2008/06/13.