4-NITRO-1-PHENYLPYRAZOLE

Base Information

• Chemical Name: 4-NITRO-1-PHENYLPYRAZOLE
• CAS No.: 3994-48-7
• Molecular Formula: C9H7N3O2
• Molecular Weight: 189.173
• Mol file: 3994-48-7.mol

Synonyms:1H-Pyrazole, 4-nitro-1-phenyl-;1-phenyl-4-nitro-1H-pyrazole;4-nitro-1-phenylpyrazole;4-nitro-1-phenyl-1H-pyrazole;1-phenyl-4-nitropyrazole;4-Nitro-1-phenyl-1H-pyrazol;

Chemical Property of 4-NITRO-1-PHENYLPYRAZOLE

Chemical Property:

• PSA: 63.64000
• LogP: 2.30370

Purity/Quality:

95% ^*data from raw suppliers

4-Nitro-1-phenyl-1H-pyrazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITRO-1-PHENYLPYRAZOLE

There total 20 articles about 4-NITRO-1-PHENYLPYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-iodo-1-phenyl 1H-pyrazole (23889-85-2) → 4-nitro-1-phenylyrazole (3994-48-7)

Guidance literature:

With nitric acid; In tetrahydrofuran; at 20 ℃; for 2.5h;

DOI:10.1080/00397911.2011.584261

Reference yield: 79.0%

4-nitro-1H-pyrazole (2075-46-9) → 4-nitro-1-phenylyrazole (3994-48-7)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;

DOI:10.3998/ark.5550190.p008.682

Reference yield: 65.0%

4-nitro-1H-pyrazole (2075-46-9) + iodobenzene (591-50-4) → 4-nitro-1-phenylyrazole (3994-48-7)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Inert atmosphere; Sealed tube;

upstream raw materials:

ethanol

1-phenylpyrazole

phenylhydrazine

β-formyl-β-nitroenamine

Downstream raw materials:

1-(2,4-dinitro-phenyl)-4-nitro-1H-pyrazole

1-phenyl-4-(pyrimidin-2-ylamino)-1H-pyrazole-5-carbonitrile

1-phenyl-4-(quinazolin-2-ylamino)-1H-pyrazole-5-carbonitrile

N-(1-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine

Refernces

• 1、 Nishiwaki, Nagatoshi,Tohda, Yasuo,Ariga, Masahiro. "Facile Synthesis of Functionalized Nitroenamines. III.1,2 Aminolysis of 1-Methyl-5-nitropyrimidin-2(1H)-one". . p. 1997 - 2002. Retrieved 1996.
• 2、 -. "HSP90 INHIBITORS AND USES THEREOF". Paragraph 00492-00493; 00494-00495. . Retrieved 2020/11/23.
• 3、 Wang, Chen-Ru,Wang, Ze-Feng,Shi, Lu,Wang, Zhong-Chang,Zhu, Hai-Liang. "Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAFV600E inhibitors". supporting information. p. 2382 - 2390. Retrieved 2018/06/25.