Loprazolam

Base Information

• Chemical Name: Loprazolam
• CAS No.: 61197-73-7
• Molecular Formula: C23H21 Cl N6 O3
• Molecular Weight: 464.911
• UNII: 759N8462G8
• DSSTox Substance ID: DTXSID30894873
• Nikkaji Number: J18.311C,J453.183C
• Wikipedia: Loprazolam
• Wikidata: Q411806
• NCI Thesaurus Code: C66032
• Metabolomics Workbench ID: 154434
• ChEMBL ID: CHEMBL2107448
• Mol file: 61197-73-7.mol

Synonyms:8-nitro-6-(o-chlorophenyl)-1,2-dihydro-2-(N-methylpiperazin-1-yl)methylene-1H,4H-imidazo (1,2-a)(1,4)benzodiazepin-1-one methanesulfonate;HR 158;HR 458;loprazolam;RU 31158;triazulenone;triazulenone mesylate;triazulenone, (Z)-isomer

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Chemical Property of Loprazolam

Chemical Property:

• Vapor Pressure: 3.07E-14mmHg at 25°C
• Melting Point: 214-215°
• Boiling Point: 597.5°C at 760 mmHg
• PKA: 6.79±0.42(Predicted)
• Flash Point: 315.1°C
• PSA: 97.33000
• Density: 1.48g/cm³
• LogP: 2.26830
• Storage Temp.: -20°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 464.1363662
• Heavy Atom Count: 33
• Complexity: 891

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)C=C2C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl
• Isomeric SMILES: CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl
• Recent EU Clinical Trials: Self-help program for hypnotics withdrawal in insomniac patients: A randomized controlled clinical trial.
• Uses: Sedative, hypnotic. Controlled substance (depressant).

Technology Process of Loprazolam

There total 2 articles about Loprazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ loprazolam (61197-73-7)

Guidance literature:

Benzodiazepinon Vc, N-Methylpiperazin;

DOI:10.1021/jm00218a009

Reference yield:

→ loprazolam (61197-73-7)

Guidance literature:

entspr.Diazepin Ia /N-Methylpiperazin;

Reference yield: 84.0%

loprazolam (61197-73-7) → 6-o-chlorophenyl-2,4-dihydro-8-nitro-2-(1-piperazinyl)methylene-1H-imidazo<1,2-a><1,4>benzodiazepin-1-one (61198-11-6)

Guidance literature:

With piperazine; In toluene; for 3h; Heating;

Downstream raw materials:

2'-chloro-5-nitro-2-aminobenzophenone

8-amino-6-o-chlorophenyl-2,4-dihydro-2-(4-methyl-1-piperazinyl)-methylene-1H-imidazo-(1,2-a)(1,4)-benzodiazepin-1-one

2-aminoacetylaminoacetylamino-5-nitro-2'-chlorobenzophenone

8-amino-6-o-chlorophenyl-2,4-dihydro-2-(4-methyl-1-piperazinyl)methylene-1H-imidazo<1,2-a><1,4>benzodiazepin-1-one

Refernces