1-[(Z)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino]-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione

Base Information

• Chemical Name: 1-[(Z)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino]-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione
• CAS No.: 149908-53-2
• Molecular Formula: C23H28ClN5O3
• Molecular Weight: 457.9531
• NCI Thesaurus Code: C79923
• Nikkaji Number: J566.960J
• Pharos Ligand ID: YJTJBSLA1VKG
• Wikidata: Q553161
• Wikipedia: Azimilide
• Mol file: 149908-53-2.mol

Synonyms:1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-2,4-imidazolidinedione dihydrochloride;2,4-Imidazolidinedione, 1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-, dihydrochloride;azimilide;azimilide dihydrochloride;azmilide;NE 10064;NE-10064

Chemical Property of 1-[(Z)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino]-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione

Chemical Property:

• Boiling Point: 594.891 °C at 760 mmHg
• PKA: 7.72±0.10(Predicted)
• Flash Point: 313.579 °C
• PSA: 72.60000
• Density: 1.32 g/cm³
• LogP: 2.97730
• Storage Temp.: 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 457.1880675
• Heavy Atom Count: 32
• Complexity: 677

Purity/Quality:

95-99% ^*data from raw suppliers

Azimilide >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)N=CC3=CC=C(O3)C4=CC=C(C=C4)Cl
• Isomeric SMILES: CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)/N=C\C3=CC=C(O3)C4=CC=C(C=C4)Cl
• Recent EU Clinical Trials: A Phase 3 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Once-Daily Oral Doses of 75 mg Azimilide Dihydrochloride on the Incidence of Cardiovascular Hospitalizations/Emergency Department Visits or Cardiovascular Death in Patients with an Implantable Cardioverter Defibrillator
• Uses: Cardiac depressant (anti-arrhythmic).
• Therapeutic Function: Antiarrhythmic
• Clinical Use: Azimilde is another Class III antiarrhythmic agent structurally unrelated to any of the above agents. Azimilide is not available in the United States; it is only available in Europe. Following oral administration, the drug is completely absorbed, with no effect of food. Protein binding is 94%. It is metabolized in the liver to an active carboxylate metabolite, but its concentration in plasma is less than 5% of the parent compound. Thus, it is considered to be therapeutically inactive. Renal excretion is approximately 10%. Its elimination half-life is 3 to 4 days.