O-(4-nitrobenzoyl)hydroxylamine

Base Information

• Chemical Name: O-(4-nitrobenzoyl)hydroxylamine
• CAS No.: 35657-36-4
• Molecular Formula: C7H6N2O4
• Molecular Weight: 182.136
• Hs Code.: 2922199090
• Mol file: 35657-36-4.mol

Synonyms:NbzONH2;4-nitrobenzoyl O-hydroxylamine;O-(4-Nitrobenzoyl)hydroxylamine;O-amino-4-nitrobenzoic acid;

Chemical Property of O-(4-nitrobenzoyl)hydroxylamine

Chemical Property:

• Melting Point: 85.0℃ (decomposition)
• Boiling Point: 361.4±44.0 °C(Predicted)
• PKA: -2.68±0.70(Predicted)
• PSA: 98.14000
• Density: 1.441±0.06 g/cm3(Predicted)
• LogP: 1.84880
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-(4-Nitrobenzoyl)hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 1966666
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of O-(4-nitrobenzoyl)hydroxylamine

There total 6 articles about O-(4-nitrobenzoyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

O-(4-nitrobenzoyl)hydroxylamine hydrochloride → O-(4-nitrobenzoyl) hydroxylamine (35657-36-4)

Guidance literature:

With sodium hydrogencarbonate; In water; at 0 - 5 ℃; for 4h;

DOI:10.1016/j.tet.2009.05.007

Reference yield: 83.0%

tert-Butyl N-hydroxycarbamate (36016-38-3) + 4-nitro-benzoyl chloride (122-04-3) → O-(4-nitrobenzoyl) hydroxylamine (35657-36-4)

Guidance literature:

tert-Butyl N-hydroxycarbamate; 4-nitro-benzoyl chloride; With triethylamine; In dichloromethane; at -5 - 0 ℃; Large scale;

With methanesulfonic acid; at 25 ℃; for 5h; Large scale;

DOI:10.1021/op300181r

Reference yield:

O-(4-nitrobenzoyl)hydroxylamine methanesulfonic acid salt (1085941-27-0) → O-(4-nitrobenzoyl) hydroxylamine (35657-36-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

4-nitro-benzoyl chloride

methanesulfonic acid

tert-butyl [(4-nitrobenzoyl)oxy]carbamate.

O-(4-nitrobenzoyl)hydroxylamine methanesulfonic acid salt

Downstream raw materials:

1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

(E)-4-chlorobenzaldehyde O-(4-nitrobenzoyl)oxime

(E)-4-methoxybenzaldehyde O-(4-nitrobenzoyl) oxime

1,2-diamino-3-methoxypyridinium 4-nitrobenzoate

Refernces

• 1、 Shi, Zhongping,Kiau, Susanne,Lobben, Paul,Hynes Jr., John,Wu, Hong,Parlanti, Luca,Discordia, Robert,Doubleday, Wendel W.,Leftheris, Katerina,Dyckman, Alaric J.,Wrobleski, Stephen T.,Dambalas, Konstantinos,Tummala, Srinivas,Leung, Simon,Lo, Ehrlic. "Development of a practical synthesis of a p38 kinase inhibitor via a safe and robust amination". . p. 1618 - 1625. Retrieved 2013/02/23.
• 2、 -. "KINESIN INHIBITORS". Page/Page column 63. . Retrieved 2009/01/20.