2-Methyl-7-(trifluoroMethyl)quinoline

Base Information

• Chemical Name: 2-Methyl-7-(trifluoroMethyl)quinoline
• CAS No.: 324-32-3
• Molecular Formula: C₁₁H₈F₃N
• Molecular Weight: 211.186
• Hs Code.: 2933499090
• Mol file: 324-32-3.mol

Synonyms:2-methyl-7-trifluoromethylquinoline;2-Methyl-7-trifluormethyl-chinolin;7-trifluoromethylquinaldine;

Chemical Property of 2-Methyl-7-(trifluoroMethyl)quinoline

Chemical Property:

• PSA: 12.89000
• LogP: 3.56200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Methyl-7-(trifluoromethyl)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-7-(trifluoroMethyl)quinoline

There total 7 articles about 2-Methyl-7-(trifluoroMethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-Hydroxy-4-methyl-2-pentanone (123-42-2) + 2-amino-4-(trifluoromethyl)benzaldehyde (109466-88-8) → 2-methyl-7-trifluoromethylquinoline (324-32-3)

Guidance literature:

With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium t-butanolate; In toluene; at 70 ℃; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6ob01452f

Reference yield: 63.0%

3-trifluoromethylaniline (98-16-8) + crotonaldehyde (123-73-9,4170-30-3) → 2-methyl-7-trifluoromethylquinoline (324-32-3)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1021/jm020845g

Reference yield: 38.0%

(E)-1-Bromo-2-butene (4784-77-4,39616-19-8,29576-14-5) + 1,2-bis(3-(trifluoromethyl)phenyl)diazene (588-00-1) → 2-methyl-7-trifluoromethylquinoline (324-32-3)

Guidance literature:

With copper(l) iodide; In 1,2-dichloro-ethane; at 120 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.5b03009

upstream raw materials:

3-trifluoromethylaniline

crotonaldehyde

trans-Crotonaldehyde

(E)-1-Bromo-2-butene

Downstream raw materials:

2-(bromomethyl)-7-(trifluoromethyl)quinoline

2-methylquinoline-7-carboxylic acid

3-(7-trifluoromethyl-2-quinolinylmethoxy)aniline

Refernces

• 1、 Zhang, Song-Lin,Deng, Zhu-Qin. "Synthesis of quinolines and naphthyridines: Via catalytic retro-aldol reaction of β-hydroxyketones with ortho -aminobenzaldehydes or nicotinaldehydes". supporting information. p. 8966 - 8970. Retrieved 2016/10/05.
• 2、 -. "TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS". Page/Page column 87-88. . Retrieved 2012/12/13.