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Name |
L-Arginine-L-pyroglutamate |
EINECS | 260-081-5 |
CAS No. | 56265-06-6 | Density | N/A |
PSA | 191.62000 | LogP | 0.23120 |
Solubility | easily soluble in cold water | Melting Point |
N/A |
Formula | C6H14N4O2.C5H7NO3 | Boiling Point | 409.1 °C at 760 mmHg |
Molecular Weight | 303.318 | Flash Point | 201.2 °C |
Transport Information | N/A | Appearance | crystalline solid powder |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
L-Arginine L-pyroglutamic acid;Adiuvant;Arginine pyroglutamate;Proline, 5-oxo-, L-, compd. with L-arginine (1:1);L-Arginine L-Pyroglutamate;Arginine pidolate;Arginina pidolato [Spanish];5-Oxo-L-proline, compound with L-arginine (1:1);L-Proline, 5-oxo-, compd. with L-arginine (1:1);G-278;Arginine PCA;(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid; (2S)-5-oxopyrrolidine-2-carboxylic acid;L-Arginine Pyroglutamate (Micropellet);L-Arginine compd. with 5-oxo-L-proline (1:1); |
1. Introduction of L-Arginine-L-pyroglutamate
L-Arginine-L-pyroglutamate, with the IUPAC name of (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid, is one kind of crystalline solid powder with a sour taste. The product's categories are Amino Acids; Nutritional Supplements. Besides, it is a delivery form of pyroglutamate, a naturally occurring amino acid that can be derived from vegetables, fruit, dairy products and meat
2. Properties of L-Arginine-L-pyroglutamate
The other characteristics of L-Arginine-L-pyroglutamate can be summarized as: (1)ACD/LogP: -1.29; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 6; (4)#H bond donors: 7; (5)#Freely Rotating Bonds: 6; (6)Polar Surface Area: 48.38 Å2; (7)Flash Point: 201.2 °C; (8)Enthalpy of Vaporization: 72.55 kJ/mol; (9)Boiling Point: 409.1 °C at 760 mmHg; (10)Vapour Pressure: 7.7E-08 mmHg at 25°C; (11)Rotatable Bond Count: 6; (12)Tautomer Count: 6; (13)Exact Mass: 303.154269; (14)MonoIsotopic Mass: 303.154269; (15)Topological Polar Surface Area: 194; (16)Heavy Atom Count: 21; (17)Complexity: 331; (18)Defined Atom StereoCenter Count: 2.
3. Structure Descriptors of L-Arginine-L-pyroglutamate
You could convert the following datas into the molecular structure:
1. SMILES:O=C(O)[C@H]1NC(=O)CC1.O=C(O)[C@@H](N)CCC/N=C(\N)N
2. InChI:InChI=1/C6H14N4O2.C5H7NO3/c7-4(5(11)12)2-1-3-10-6(8)9;7-4-2-1-3(6-4)5(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);3H,1-2H2,(H,6,7)(H,8,9)/t4-;3-/m00/s1
3. InChIKey:UYCAGRPOUWSBIQ-WOYAITHZBM
4. Uses of L-Arginine-L-pyroglutamate
L-Arginine-L-pyroglutamate is used to stimulate the pancreatic and pituitary axis has been used to alleviate growth retardation in children and to promote growth hormone release in endurance athletes or body builders. It also has been widely used because of its role in synthesis of urea, nitric oxide (NO), and creatine.
5. Toxicity of L-Arginine-L-pyroglutamate
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD50 | intravenous | 1gm/kg (1000mg/kg) | Medicamentos de Actualidad. Vol. 17, Pg. 85, 1981. | |
rat | LD50 | oral | 6gm/kg (6000mg/kg) | Medicamentos de Actualidad. Vol. 17, Pg. 85, 1981. |