Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Hispidulin	EINECS	N/A
CAS No.	1447-88-7	Density	1.512 g/cm³
PSA	100.13000	LogP	2.58540
Solubility	N/A	Melting Point	291-292 °C
Formula	C₁₆H₁₂O₆	Boiling Point	601.506 °C at 760 mmHg
Molecular Weight	300.268	Flash Point	230.135 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	22
Molecular Structure		Hazard Symbols	Xn
Synonyms	6-Methylscutellarein;6-O-Methylapigenin;6-O-Methylscutellarein;Dinatin;Hispedulin;NSC122415;Salvitin;Scutellarein 6-methyl ether;Flavone,4',5,7-trihydroxy-6-methoxy- (7CI,8CI);4',5,7-Trihydroxy-6-methoxyflavone;5,7,4'-Trihydroxy-6-methoxyflavone;6-Methoxy-5,7,4'-trihydroxyflavone;6-Methoxyapigenin;	Article Data	18

Hispidulin Synthetic route

: 28736-83-6
7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-hydroxy-6-methoxy-4H-chromen-4-one

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol under 760.051 Torr; for 8h; Inert atmosphere;	96%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol under 760.051 Torr; for 8h;	96%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol for 8h;	96.1%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol at 20℃; for 8h;	96%

: 5-hydroxy-6-methoxy-7-(methoxymethoxy)-2-(4-(methoxymethoxy)phenyl)-4H-chromen-4-one

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at 0 - 25℃; for 1h;	92%
With hydrogenchloride In diethyl ether; dichloromethane; water at 0 - 25℃; for 1h;

: hispidulin-7-O-β-D-methylglucuronopyranoside

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With sulfuric acid In ethanol; water at 20 - 100℃; Solvent; Temperature; Reagent/catalyst;	91%
With sulfuric acid In ethanol; water at 100℃; Inert atmosphere;	90%

: 4'-benzyloxy-6-methoxy-5-benzyloxy-7-hydroxyflavone

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at -78℃; for 1.33333h;	85%
With boron trichloride In dichloromethane at -78℃; for 1.33333h;	85%

: 4'-benzyloxy-6-methoxy-5,7-dihydroxyflavone

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at -78 - 20℃; for 1h; Inert atmosphere;	80%

: 17680-84-1
tectoridin

A: 2280-44-6
D-Glucose

B: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With hydrolysis

: 5,7-dihydroxy-6-methoxy-flavone-4'-O-neohesperidoside

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With sulfuric acid for 8h;	95 mg

: 7-benzyloxy-2-(4-benzyloxy-phenyl)-5,6-dimethoxy-chromen-4-one

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at -65℃; for 1.5h;

: 90-24-4
2-hydroxy-4,6-dimethoxyacetophenone

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 2: 99 percent / K2CO3 / acetone / Heating 3: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 4: 59 percent / K2CO3 / acetone / Heating 5: pyridine / 3 h / 20 °C 6: KOH / pyridine / 4 h / 60 °C 7: sulfuric acid / acetic acid / 1.5 h / 60 °C 8: BCl3 / CH2Cl2 / 1.5 h / -65 °C View Scheme

: 1486-50-6
4-(benzyloxy)benzoic acid chloride

: 1447-88-7
hispidulin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / 3 h / 20 °C 2: KOH / pyridine / 4 h / 60 °C 3: sulfuric acid / acetic acid / 1.5 h / 60 °C 4: BCl3 / CH2Cl2 / 1.5 h / -65 °C View Scheme

Hispidulin Specification

The IUPAC name of Hispidulin is 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one. With the CAS registry number 1447-88-7, it is also named as 4',5,7-Trihydroxy-6-methoxyflavone. The product's category is Miscellaneous Natural Products. In addition, this chemical is partial positive allosteric modulator at the benzodiazepine receptor. It is used as brain penetrant. And it also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

The other characteristics of Hispidulin can be summarized as: (1)ACD/LogP: 1.60; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.54; (4)ACD/LogD (pH 7.4): 0.39; (5)ACD/BCF (pH 5.5): 8.4; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 153.57; (8)ACD/KOC (pH 7.4): 11; (9)H bond acceptors: 6; (10)H bond donors: 3; (11)Freely Rotating Bonds: 5; (12)Polar Surface Area: 63.22 Å²; (13)Index of Refraction: 1.697; (14)Molar Refractivity: 76.53 cm³; (15)Molar Volume: 198.5 cm³; (16)Polarizability: 30.33×10^-24cm³; (17)Surface Tension: 72.8 dyne/cm; (18)Density: 1.512 g/cm³; (19)Flash Point: 230.1 °C; (20)Enthalpy of Vaporization: 92.8 kJ/mol; (21)Boiling Point: 601.5 °C at 760 mmHg; (22)Vapour Pressure: 4.61E-15 mmHg at 25 °C

People can use the following data to convert to the molecule structure.
(1)SMILES:O=C\1c3c(O)c(OC)c(O)cc3O/C(=C/1)c2ccc(O)cc2
(2)InChI:InChI=1/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
(3)InChIKey:IHFBPDAQLQOCBX-UHFFFAOYAV
(4)Std. InChI:InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
(5)Std. InChIKey:IHFBPDAQLQOCBX-UHFFFAOYSA-N

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 1447-88-7