Synthetic Communications p. 3757 - 3771 (1996)
Update date:2022-08-22
Topics:
Khilevich, Albert
Rizzo, John D.
Flavin, Michael T.
Sheinkman, Abram K.
Mar, Aye
Kucherenko, Alla
Yan, Changren
Dzekhtser, Sergey
Brankovic, Darko
Lin, Lin
Liu, Jinjun
Rizzo, Thomas M.
Xu, Ze-Qi
Combined aldol/Mitsunobu reactions have been employed for the first time for synthesis of 2,3-dimethyl chroman-4-ones, intermediates for calanolide anti-HIV agents. Thus, the lithium enolate of chromene 1 reacted with acetaldehyde at -78°C to afford the aldol products 4 and 5. Under Mitsunobu conditions (Ph3P/DEAD), the syn aldol product 4 led to the formation of trans-2,3-dimethyl chroman-4-one 2 while the anti aldol product 5 yielded both trans and cis derivative (2 and 3). The use of other phosphorous and azo compounds in this reaction has also been investigated.
View MoreShaanxi King Stone Enterprise Company Limited
Contact:86-29-88353805,13609285751
Address:.209 Keji Road Hi-Tech industrial Develpment Zone .Xian China
Xiamen Kaijia Imp & Exp Co., Ltd.
Contact:86-592-5101177
Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
zhengzhou Triz Pharma-Tech Co., Ltd
website:http://www.Trizpharma-tech.com
Contact:+86-0371-86597269,53392065
Address:High-tech Industrial Development Zone, Zhengzhou City, NO.7 Holly Street
Nanjing Capatue Chemical Co., Ltd
Contact:+86-25-86371192 +86-025-85720158
Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Daqing New Century Fine Chemical Co., Ltd.
Contact:010-57126694
Address:No.39, jinxing cun, honggang district
Doi:10.1016/0040-4020(96)00099-3
(1996)Doi:10.1002/hlca.193802101214
(1938)Doi:10.1016/S0040-4039(00)94367-3
(1990)Doi:10.1021/acs.inorgchem.7b02582
(2017)Doi:10.1039/d0cc00952k
(2020)Doi:10.1007/BF00475474
(1987)