910
H. Liu et al.
N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-
pyrimidinamine (5)
washed with water, dried, and purified with 20 cm3 ethyl
acetate to afford product 1 as an off-white solid (2.1 g,
91%). M.p.: 210–212 °C (Ref. [9] 206–209 °C).
To a mixture of 9.34 g N-(2-methyl-5-nitrophenyl)form-
amide (0.052 mol) and 7.88 g K2CO3 (0.057 mol) in
30 cm3 DMF at 80 °C, a solution of 12.2 g compound 4
(0.052 mol) in 10 cm3 DMF was added and reacted for 8 h
at 80 °C. The mixture was cooled to room temperature,
poured into an aqueous solution of sodium hydroxide (2 M,
100 cm3), and stirred for 30 min. The precipitate was
filtered and washed with water to give 5 as a yellow solid
(14.1 g, 88%). M.p.: 192–193 °C (Ref. [7] 194–195 °C).
Acknowledgments We gratefully acknowledge the financial sup-
port from the Shanghai Science and Technology Mission
(10ZR1409600) and the Program for New Century Excellent Talents
in University (NCET). We also thank the Laboratory of Organic
Functional Molecules, the Sino-French Institute of ECNU for support.
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To a stirred suspension of 10.0 g compound 5 (32.5 mmol)
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A solution of 30.0 g compound 8 (0.198 mol) in 50 cm3
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4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[4-
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benzamide (1)
To a stirred suspension of 2.0 g compound 9 (6.5 mmol)
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for 2 h at 50 °C. Then 1.3 g amine 6 (4.7 mmol) was
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123