Nucleosides and Nucleotides p. 1445 - 1451 (1998)
Update date:2022-08-29
Topics:
Dang, Qun
Liu, Yan
Erion, Mark D.
A new regio-defined synthesis of PMEA was developed suitable for gramscale synthesis. Key to this synthesis was the early introduction of the phosphonomethoxy ethyl moiety and subsequent cyclization for the construction of the purine ring. This synthesis is regiospecific when compared to the commonly used adenine alkylation methods.
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