Phosphorus, Sulfur and Silicon and the Related Elements p. 1 - 25 (2001)
Update date:2022-08-28
Topics:
Mizrahi, Dana M.
Waner, Trevor
Segall, Yoffi
Eleven new bisphosphonates were prepared from naturally-occurring l-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid-induced hypercalcemia and were compared to alendronate. Most of the compounds showed moderate to no anti-resorptive activity. Two compounds were more active than clodronate, but less than alendronate. Limited SAR conclusions were drawn.
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