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V. Mirkhani et al.
General Procedure for Formylation of Alcohols with Ethyl Formate Catalyzed
by (NH4)8[CeW10O36]ꢁ20H2O
Alcohol (1mmol) and 0.04 mmol of catalyst were mixed together in 3 cm3 of ethyl formate. The
reaction mixture was stirred under reflux. The progress of the reaction was monitored by GLC. The
solution was evaporated under reduced pressure and 20cm3 of ether were added. The reaction mixture
was washed with H2O and dried (Na2SO4). Evaporation of the solvent followed by chromatography on
a short column of silica-gel gave the pure formate.
Catalyst Reuse and Stability
The stability of (NH4)8[CeW10O36]ꢁ20H2O was studied in repeated acetylation reactions. The acetyla-
tion of 1-heptanol with Ac2O was chosen as a model substrate for studying of catalyst’s reuse and
stability. The reaction was carried out as described above. At the end of each reaction, the catalyst was
removed by filtration, washed with H2O and acetone, and reused. After the use of catalyst for four
consecutive cycles, the yield of 1-heptyl acetate produced from the reaction of 1-heptanol with acetic
anhydride was 99% and after six times was 86%.
Acknowledgment
The authors wish to thank Isfahan University Research Council for financial support.
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