Journal of Organic Chemistry p. 11047 - 11059 (2020)
Update date:2022-08-15
Topics: Synthesis Unprotected Transamination 2-Arylglycines Arylglyoxylic Acids 2-(2-Chlorophenyl)glycine
Inada, Haruki
Shibuya, Masatoshi
Yamamoto, Yoshihiko
The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.
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