Bioorganic and Medicinal Chemistry Letters p. 2731 - 2736 (1999)
Update date:2022-08-05
Topics:
Zhang, Jin-Sheng
Ding, Jian
Tang, Qin-Mei
Li, Mai
Zhao, Ming
Lu, Li-Juan
Chen, Ling-Ji
Yuan, Sheng-Tao
A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.
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