Journal of Medicinal Chemistry p. 1618 - 1623 (1992)
Update date:2022-09-26
Topics:
Nihro, Yasunori
Sogawa, Satoshi
Izumi, Akihiro
Sasamori, Akihiro
Sudo, Tadamitsu
et al.
Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury.These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats.We found that 3-O-<(dodecylcarbonyl)methyl>ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.
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