- Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies
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A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 μg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
- Gemma, Sandra,Savini, Luisa,Altarelli, Maria,Tripaldi, Pierangela,Chiasserini, Luisa,Coccone, Salvatore Sanna,Kumar, Vinod,Camodeca, Caterina,Campiani, Giuseppe,Novellino, Ettore,Clarizio, Sandra,Delogu, Giovanni,Butini, Stefania
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scheme or table
p. 6063 - 6072
(2009/12/09)
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- THERAPEUTIC AGENTS I
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Compounds of formula(I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders, and pharmaceutical compositions containing them.
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Page/Page column 40
(2010/02/12)
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