- NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
-
The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
- -
-
Page/Page column 169; 170
(2019/05/22)
-
- COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA
-
The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.
- -
-
Page/Page column 73; 74
(2014/10/15)
-
- Platinum(II) complexes with thiourea derivatives containing oxygen, sulfur or selenium in a heterocyclic ring: Computational studies and cytotoxic properties
-
Platinum(II) complexes with 1-(2-oxolanylmethyl)-2-thiourea, 1-(2-thiolanylmethyl)-2-thiourea and 1-(2-selenolanylmethyl)-2-thiourea were synthesized in order to compare their cytotoxic activities with those of the free thioureas. Their equilibrium geometries and bonding energies in the gas phase and in solution were calculated using density functional theory at the MPW1PW/LanL2DZ level. The IR spectra of the complexes and their free ligands were compared. Stability of the complexes in 0.9% saline aqueous solution was tested by means of HPLC. The cytotoxic activities of the species against five human cell lines were evaluated, as well as the antimicrobial activities against twelve bacterial strains. Springer Science+Business Media B.V. 2010.
- Fuks,Anuszewska,Kruszewska,Krowczynski,Dudek,Sadlej-Sosnowska
-
experimental part
p. 639 - 647
(2011/11/12)
-
- A PROCESS FOR THE PREPARATION OF 3- [ (2R) TETRAHYDROFURAN-2- YLMETHYL] -2-THIOXO-L, 2, 3, 7-TETRAHYDRO-6H-PURIN-6-ONE
-
The present invention relates to a new and more efficient process suitable for large scale preparation of 3-[(2R)tetrahydrofuran-2-ylmethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one.
- -
-
Page/Page column 12
(2010/07/02)
-