New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids
We synthesized proline and pyrrolidine-2-alkanoic acid derivatives in their enantiomerically pure form and evaluated them for their affinity to the GABA transport proteins GAT-1 and GAT-3. Among the compounds presented herein, (R)-pyrrolidine-2-acetic aci
Fuelep, Guenther H.,Hoesl, Cornelia E.,Hoefner, Georg,Wanner, Klaus T.
p. 809 - 824
(2007/10/03)
Contribution to the asymmetric synthesis of bicyclic compounds catalysed by optically active amino acids. Synthesis of (S)-2-pyrrolidinepropionic acid and (R)-4-amino-5-phenylvaleric acid
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Buchschacher,Cassal,Furst,Meier
p. 2747 - 2755
(2007/10/06)
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