- Novel quinazoline derivative LU1506, preparation method and applications thereof
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The invention discloses a novel quinazoline derivative LU1506 and a preparation method thereof. The derivative is chemically named as N-{[(4-dimethylamino)phenyl]methyl}-4-N-[7-methoxyl-6-(2-pyrrolidyl)hydroxyethyl]quinazoline-4-yl}benzene-1,4-diamine. The provided quinazoline derivative, pharmaceutically acceptable salts, solvates, and hydrates thereof have an excellent in-vitro/in-vivo antitumor activity on MCF-7, SK-BR-3, MDA-MB-468, U-118 MG, HTC116, and U-87 MG, and can be used to prepare antitumor drugs.
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Paragraph 0036; 0037
(2016/11/14)
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- A novel quinazoline derivative LU1505 and its preparation method and application (by machine translation)
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The invention discloses a novel quinazoline derivative LU1505 and its preparation method, its chemical named N-{ [(4-dimethylamino) phenyl] methyl} - 4-N - [7-methoxy-6 - (2-pyrrolidin-1-yl) ethoxyl] quinazolin -4 yl} benzene -1,4-diamine. Quinazoline derivatives of the present invention and its pharmaceutically acceptable salts, solvates, and hydrate the MCF-7, SK-BR-3, A172, HCT? 116, U -118 mg, U -87 mg, MDA-MB-468 has outstanding kilograms of in vivo anti-tumor, anti-tumor drug in the preparation has better application prospect. (by machine translation)
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Paragraph 0034; 0035
(2016/11/21)
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