- Physical, chemical, and isotopic (atomic) labels
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Chemical or isotopic labels are added to, e.g., a potentially lethal drug formulation, to generate a unique chemical fingerprint. Combinations of chemical additives are mixed with the drug to aid in their isolation and identification, especially when such drugs are used for illicit purposes. When stable isotopes are incorporated into lethal drugs, the labeling process conveys a very unique internal chemical signature and greatly aids in the identification of the parent drug in body fluids and tissues. When heath-care providers become aware that certain drugs can now be easily tracked and identified in a victim, individuals may be reluctant to utilize these agents for ill purposes.
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- Dications of fluorenylidenes. The effect of substituent electronegativity and position on the antiaromaticity of substituted tetrabenzo[5.5]fulvalene dications
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Oxidation of 3,6-disubstituted tetrabenzo[5.5]fulvalenes by SbF5 results in the formation of dications that behave like two antiaromatic fluorenyl cations connected by a single bond. Both fluorenyl systems exhibit the paratropic shifts and nucleus independent chemical shifts (NICS) characteristic of antiaromatic species. Comparison with analogous 2,7-disubstituted tetrabenzo[5.5]fulvalenes reveals that the antiaromaticity of the substituted ring system can be altered substantially by changes in the placement of the substituents, possibly due to changes in the delocalization of charge in the system. Substituents in the 3,6-position decrease the antiaromaticity because of the increase in the benzylic resonance compared to 2,7-substituents.
- Levy, Amalia,Rakowitz, Amber,Mills, Nancy S.
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p. 3990 - 3998
(2007/10/03)
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- Macrocyclic plant acaricides
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Compounds of the formula I STR1 in which either R is methyl and there is a double bond in the 9,10-position, or in which R is hydrogen and there is a single bond in the 9,10-position, are highly active against Acarina which damage plants.
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- Photoinduced Reaction : Part III - Photodegradation of p,p'-Dichlorodiphenyl-2,2,2-trichloroethanol (Dicofol), an Important Miticide
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Dicofol (p,p'-dichlorodiphenyl-2,2,2-trichloroethanol) on photolysis undergoes a variety of changes involving addition of solvent radicals, reduction and oxidation.The degradation products have been isolated and characterised.In the solid state also it undergoes photodegradation to p,p'-dichlorobenzophenone (2).In alcoholic solution in the presence of radical quenchers like iodine and paraffin chlorobenzilic esters (6 and 9) are formed in high yields.Irridiation of dil. aqueous solution of 1 by sunlight brings about complete degradation to non-toxic products.Radical mechanism has been proposed for the formation of these products.
- Vaidyanathaswamy,Dureja, P.,Mukerjee, S. K.
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p. 866 - 869
(2007/10/02)
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- Alkyl 4-[o-(substituted methyleneamino)-phenyl]-3-thioallophanate miticides and fungicides
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Various alkyl 4-[o-(substituted methyleneamino)phenyl]3-thioallophanates are useful as fungicides and mite ovicides. The compounds are prepared by reacting alkyl 4-(o-aminophenyl)-3-thioallophanates with aldehydes or trialkyl orthoformates. Some of the compounds are prepared by further reacting the reaction product of an alkyl 4-(o-aminophenyl)-3-thioallophanate and a trialkyl orthoformate with a primary or secondary amine. Exemplary species are methyl 4-[o-(o-fluorobenzylideneamino)phenyl]-3-thioallophanate, methyl 4-[o-(4-methylbenzylideneamino)phenyl]-3-thioallophanate and methyl 4-[o-(2-furfurylideneamino)phenyl]-3-thioallophanate.
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- Alkyl 4-[o-(substituted methyleneamino)phenyl]-3-thioallophanates
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Various alkyl 4-[o-(substituted methyleneamino)phenyl] 3-thioallophanates are useful as fungicides and mite ovicides. The compounds are prepared by reacting alkyl 4-(o-aminophenyl)-3-thioallophanates with aldehydes or trialkyl orthoformates. Some of the compounds are prepared by further reacting the reaction product of an alkyl 4-(o-aminophenyl)-3-thioallophanate and a trialkyl orthoformate with a primary or secondary amine. Exemplary species are methyl 4-[o-(o-fluorobenzylideneamino)phenyl]-3-thioallophanate, methyl 4-[o-(4-methylbenzylideneamino)phenyl]-3-thioallophanate and methyl 4-[o-(2-furfurylideneamino)phenyl]-3-thioallophanate.
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- Pesticidal alkyl 4-(0-(substituted methyleneamine)-phenyl)-3-thioallophanates
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Various alkyl 4-[o-(substituted methyleneamino)phenyl] 3-thioallophanates are useful as fungicides and mite ovicides. The compounds are prepared by reacting alkyl 4-(o-aminophenyl)-3-thioallophanates with aldehydes or trialkyl orthoformates. Some of the compounds are prepared by further reacting the reaction product of an alkyl 4-(o-aminophenyl)-3-thioallophanate and a trialkyl orthoformate with a primary or secondary amine. Exemplary species are methyl 4-[o-(o-fluorobenzylidine-amino)phenyl]-3-thioallophanate, methyl 4-[o-(4-methylbenzyl-ideneamino)phenyl]-3-thioallophanate and methyl 4-[o-(2-furfuryl-ideneamino)phenyl]-3-thioallophanate.
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