- Studies on the Syntheses of Heterocyclic Compounds containing Benzopyrone. Part 5. Total Synthesis of Fulvic Acid
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Total synthesis of fulvic acid (1a) is described.Regioselective cyclization of the enedione (8f), an equivalent of the proposed biogenetic intermediate (5a) for citromycetin (2), gave the pyrone (11a), which led to fulvic acid (1a) by a route involving debenzylation, selective ozonization, and hydration.
- Yamauchi, Masashige,Katayama, Sadamu,Todoroki, Toshiharu,Watanabe, Toshio
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p. 389 - 394
(2007/10/02)
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- Total Synthesis of Fulvic Acid
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Synthesis of fulvic acid (1a) was accomplished by a route involving selective ozonization of 9-propenylpyranobenzopyran (1c), obtained by a regioselective cyclization of the 2-methylsulphinylmethyl 1,3-dione (3c).
- Yamauchi, Masashige,Katayama, Sadamu,Todoroki, Toshiharu,Watanabe, Toshio
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p. 1565 - 1566
(2007/10/02)
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- THE BIOSYNTHESIS OF FULVIC ACID, A FUNGAL METABOLITE OF HEPTAKETIDE ORIGIN
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Analyses of the regiochemistry of acetate incorporation into fulvic acid (2) by Penicillium brefeldianum indicates that the metabolite is biosynthesized via a heptaketide intermediate assembled as a single chain of seven C2 units rather than from two smaller polyketide chains.This information favours a route leading through common C14 intermediates to the three fungal metabolites, citromycetin, fulvic acid and fusarubin.
- Kurobane, Itsuo,Hutchinson, C. Richard,Vining, Leo C.
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p. 493 - 496
(2007/10/02)
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