- Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
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The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
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Page/Page column 44-45
(2010/02/14)
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- Protected aminothiazolylacetic acid derivatives
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Described is a protected aminothiazolylacetic acid derivative represented by the following formula (I): STR1 wherein A represents a nitrogen atom or a methine group, R1 and R2 may be the same or different and individually represent a hydrogen atom, a lower alkyl group or a substituted or unsubstituted aryl group, R3 represents a lower alkoxy group, a halogenated lower alkoxy group, a triphenylmethoxy group, a lower alkyl group or an acyloxy group, and R4 represents a halogen atom, a hydroxy group, a lower alkoxy group or a substituted or unsubstituted amino group; and salts thereof; as well as processes for the preparation thereof. The protected aminothaizolylacetic acid derivative according to the present invention is an useful intermediate for introducing a 2-(2-aminothiazol-4-yl)-2-alkoxyiminoacetyl group or a 2-(2-aminotiazol-4-yl)-2-alkenoyl group into a cephem skeleton.
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- Efficient perfacial derivatization of cyclodextrins at the primary face
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Synthesis of thirteen cyclodextrin (CD) derivatives via the per-6-bromo-6-deoxy-CD is reported in order to demonstrate the efficiency and ease of perfacial functionalization of α, β and γCD employing a Vilsmeier-Haack reagent.
- Gorin, Boris I.,Riopelle, Richard J.,Thatcher, Gregory R. J.
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p. 4647 - 4650
(2007/10/03)
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- HALOQUASIPHOSPHONIUM SALTS IN REACTIONS WITH ALDEHYDES
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Quasiphosphonium salts with a P-Br bond, prepared from tris( fluoroalkyl ) phosphites and bromine, readily react with benzaldehyde, propanal, and DMF via a dihalodeoxygenation route.Reaction of tris(2,2,2-trifluoroethoxy)bromophosphonium bromide with chloral yields bis(2,2,2-trifluoroethyl) 1-bromo-2,2,2-trichloroethyl phosphate and 2,2,2-trifluoroethyl bromide.The ability of bromophosphonium salts to form with chloral only phosphates was used for studying intermediate products in the reaction of tris(2,2,2-trifluoroethyl) phosphite with cyanogen bromide in the presence of chloral.The reaction proceeds by the halogenophilic mechanism.
- Mironov, V. F.,Konovalova, I. V.,Burnaeva, L. M.
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p. 351 - 355
(2007/10/03)
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- VILSMEIER REAGENTS: PREPARATION OF β-HALO-α,β-UNSATURATED KETONES
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A new method for the preparation of β-chloro and β-bromo-α,β-unsaturated ketones from β-diketones is described.Utilizing Vilsmeier reagents (prepared from N,N-dimethylformamide and oxalyl chloride or oxalyl bromide) β-halo-α,β-unsaturated ketones are isolated in excellent yields.
- Mewshaw, Richard E.
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p. 3753 - 3756
(2007/10/02)
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