cas 2438-72-4, Bufexamac | Articles data

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Hydroxamic acid inhibitors of 5-lipoxygenase: Quantitative structure-activity relationships
An evaluation of the quantitative structure-activity relationships (QSAR) for more than 100 hydroxamic acids revealed that the primary physicochemical feature influencing the in vitro 5-lipoxygenase inhibitory potencies of these compounds is the hydrophobicity of the molecule. A significant correlation was observed between the octanol-water partition coefficient of the substituent attached to the carbonyl of the hydroxamate and in vitro inhibitory activity. This correlation held for hydroxamic acids of diverse structure and with potencies spanning 4 orders of magnitude. Although the hydrophobicity may be packaged in a variety of structural ways and still correlate with potency, the QSAR study revealed two major exceptions. Specifically, the hydrophobicity of portions of compounds in the immediate vicinity of the hydroxamic acid functionally does not appear to contribute to increased inhibition and the hydrophobicity of fragments beyond approximately 12 A from the hydroxamate do not influence potency. The QSAR study also demonstrated that inhibitory activity was enhanced when there was an alkyl group on the hydroxamate nitrogen, when electron-withdrawing substituents were present and when the hydroxamate was conjugated to an aromatic system. These observations provide a simple description of the lipoxygenase-hydroxamic acid binding site.
Summers,Kim,Mazdiyasni,Holms,Ratajczyk,Stewart,Dyer,Carter
p. 992 - 998
(2007/10/02)

A new anti-inflammatory agent of non-steroid structure: p-butoxyphenylacethydroxamic acid
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Buu-Ho?,Lambelin,Lepoivre,Gillet,Gautier,Thiriaux
p. 2259 - 2262
(2007/10/05)

Chemical Properties

Appearance/Colour :Acicular crystal
Melting Point: 161 - 162oC
Boiling Point: 364.56°C (rough estimate)
Density: 1.12 g/cm³
Solubility:Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol.
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
Refractive Index: 1.53
PKA: 9.24±0.20(Predicted)
Merck: 14,1474
PSA: 58.56000
LogP: 2.30430

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Chemical Properties

Appearance/Colour :Acicular crystal

Melting Point: 161 - 162oC

Boiling Point: 364.56°C (rough estimate)

Density: 1.12 g/cm³

Solubility:Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol.

Storage Temp.:Inert atmosphere,Store in freezer, under -20°C

Refractive Index: 1.53

PKA: 9.24±0.20(Predicted)

Merck: 14,1474

PSA: 58.56000

LogP: 2.30430

Global suppliers and manufacturers of 2438-72-4total 94 suppliers on LookChem

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2438-72-4

Articles about 2438-72-4Total 2 be found

More Articles about upstream products of 2438-72-4

Chemical Properties

Appearance/Colour :Acicular crystal

Melting Point: 161 - 162oC

Boiling Point: 364.56°C (rough estimate)

Density: 1.12 g/cm3

Solubility:Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol.

Storage Temp.:Inert atmosphere,Store in freezer, under -20°C

Refractive Index: 1.53

PKA: 9.24±0.20(Predicted)

Merck: 14,1474

PSA: 58.56000

LogP: 2.30430

Global suppliers and manufacturers of 2438-72-4total 94 suppliers on LookChem

Density: 1.12 g/cm³