Synthetic studies on diterpenoid quinones with interleukin-1 inhibitory activity. Total synthesis of (±)- and (+)-triptoquinone A
An efficient first total synthesis of (±)- and (+)-triptoquinone A (1), a novel diterpenoid quinone with significant inhibitory activity against interleukin-1 releases, has been completed. Birch reduction of tricyclic enone (±)-7, prepared from known 6-me
Shishido,Goto,Miyoshi,Takaishi,Shibuya
p. 406 - 414
(2007/10/02)
TOTAL SYNTHESIS OF (+/-)-TRIPTOQUINONE A
A concise and practical total synthesis of (+/-)-triptoquinone A (1), a novel interleukin-1 inhibitor isolated from Tripterygium wilfordii var. regelii, has been achieved in 11 steps from the known naphthol 2.