- Preparation method of thifluzamide
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The invention belongs to the technical field of pesticide chemistry, and particularly relates to a preparation method of thifluzamide. The preparation method comprises the following steps: with 2-methyl-4-trifluoromethyl-5-thiazolecarboxylic acid as a raw material, performing an acylating chlorination reaction on the raw material and an acylating chlorination reagent in a solvent under the actionof a catalyst, then performing an amidation and condensation reaction on a product and 2,6-dibromo-4-trifluoromethoxyaniline under the catalytic action to obtain a final product thifluzamide. The thifluzamide product prepared by the preparation method provided by the invention has the yield range of 87-92% and the crude product content being higher than or equal to 96%; by the preparation method,the operation is simple, acyl chloride is not required to be purified, the preferred catalyst has an obvious effect and the overall reaction cycle is short.
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Page/Page column 4-7
(2019/03/08)
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- Novel technology of preparing thifluzamide from thiazole acid
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The invention provides a novel technology of preparing thifluzamide from thiazole acid. The invention relates to a preparation method of a bactericide namely thifluzamide, and belongs to the technicalfield of chemistry. The invention discloses a one-step synthesis method of thifluzamide, and the synthesis method is simple and high efficient. According to the synthesis method, 2-methyl-4-trifluoromethyl-1,3-thiazole formic acid and 2,6-dibromo-trifluoromethoxyl aniline are taken as the primary raw materials, and the bactericide namely thifluzamide is synthesized in one step without any intermediate treatment in the presence of a catalyst. The novel technology has the advantages that the step is simple, there are few post treatment steps, and the reaction period is shortened.
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Paragraph 0010-0012
(2018/06/04)
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- Pyrazolyl benzyl ether derivatives containing a fluoromethoxyimino group and use thereof as pesticides
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The invention relates to novel pyrazolyl benzyl ethers, to a plurality of processes for their preparation and to their use for controlling harmful organisms.
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- Thifluzamide with improved efficacy
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PCT No. PCT/JP97/00613 Sec. 371 Date Nov. 24, 1998 Sec. 102(e) Date Nov. 24, 1998 PCT Filed Feb. 28, 1997 PCT Pub. No. WO97/31908 PCT Pub. Date Sep. 4, 1997The present invention provides thifluzamide which has changed its crystalline form, its preparation method, and a pesticide composition containing thifluzamide as its effective ingredient. The rate of dissolution of the thifluzamide obtained is high and the pesticide compounds containing it has improved efficacy.
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- Thifluzamide with stabilized efficacy
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The disclosed invention is thifluzamide with an altered crystalline form, prepared by heat-melting and then cooling, and agricultural chemical compositions comprising such a thifluzamide as its effective ingredient.
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- Thifluzamide polymorph with improved efficacy
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The disclosed invention is thifluzamide with an altered crystalline form, prepared by heat-melting and then cooling, and agricultural chemical compositions comprising such a thifluzamide as its effective ingredient.
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