- Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase
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(Chemical Equqation Presented). Sixteen new lanostane triterpenes, ganoleucoins A-P (1-16), together with 10 known tripterpenes (17-26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1-26 on HMG-CoA reductase and α-glucosidase were tested in vitro. Compounds 1, 3, 6, 10-14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against α-glucosidase from yeast with IC50 values of 13.6, 2.5, and 5.9 μM, respectively. In addition, the cytotoxicity of 1-26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC50 values in the range 10-20 μM. Paclitaxel was used as the positive control with an IC50 value of 0.9 μM. This is the first report of secondary metabolites from this medicinal mushroom.
- Wang, Kai,Bao, Li,Xiong, Weiping,Ma, Ke,Han, Junjie,Wang, Wenzhao,Yin, Wenbing,Liu, Hongwei
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- Triterpene-farnesyl hydroquinone conjugates from Ganoderma sinense
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Three new lanostane-type triterpenoids having farnesyl hydroquinone moieties, named ganosinensins A-C (1-3), were isolated from the fruiting body of Ganoderma sinense, together with three known lanostane triterpenes, ganodermanontriol, ganoderiol A, and g
- Sato, Naoto,Ma, Chao-Mei,Komatsu, Katsuko,Hattori, Masao
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- Ganoweberianones A and B, Antimalarial Lanostane Dimers from Cultivated Fruiting Bodies of the Basidiomycete Ganoderma weberianum
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Two lanostane dimers, ganoweberianones A (1) and B (2), together with seven previously undescribed lanostanes, ganoweberianic acids A-G (3-9), and three known compounds (10-12), were isolated from the artificially cultivated fruiting bodies of the basidiomycete Ganoderma weberianum. Ganoweberianone A (1) exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with an IC50 value of 0.050 μM. A method for semisynthesis of 1 by condensation of the corresponding lanostane monomers and acid-catalyzed intramolecular transesterification was demonstrated.
- Isaka, Masahiko,Chinthanom, Panida,Vichai, Vanicha,Sommai, Sujinda,Choeyklin, Rattaket
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- Process for preparing delta-7,9(11) steroids from Ganoderma lucidum and analogs thereof
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Processes for preparing lanostane triterpenes from the medicinal mushroom Ganoderma lucidum, and related compounds are described. Compounds, compositions, and methods for treating cancer are also described.
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Page/Page column 27-28; 34
(2016/08/03)
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- Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols
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The first synthesis of ganodermanontriol, a bioactive lanostane triterpene from the medicinal mushroom Ganoderma lucidum, has been achieved in 15.3% yield over nine steps, along with its three stereoisomeric triols and ganoderol A. The key steps leading t
- Kennedy, Erin M.,P'Pool, Steven J.,Jiang, Jiahua,Sliva, Daniel,Minto, Robert E.
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p. 2332 - 2337
(2012/01/15)
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