- Solvent-free phase-transfer-catalysis synthesis of 2,2'-methylene-bis[4-tert-octyl-6-(2H-benzotriazolyl-2)]phenol
-
The invention relates to a method for synthesizing 2,2'-methylene-bis[4-tert-octyl-6-(2H-benzotriazolyl-2)]phenol (UV-360) through solvent-free phase transfer catalysis. The method comprises the procedures: adding UV-329, powdered sodium hydroxide, bis(di-n-propylamino)methane and a small amount of phase transfer catalyst into a reaction bulb which is equipped with a stirrer, a thermometer and a distillate receiving device, heating the reaction bulb to the temperature of about 120 DEG C with stirring, carrying out a reaction for 2 to 3 hours at this temperature and vacuum (100mmHg), and meanwhile, carrying out distilling-off so as to produce di-n-propyl amine; and after the reaction ends, carrying out procedures, such as toluene extraction, hydrochloric acid neutralization, crystallization and filtration, thereby obtaining the product. The synthesis method has the advantages that the reaction temperature is low, the reaction time is short, the yield and quality of the product are high, di-n-propyl amine is easy to recover, and the like.
- -
-
Paragraph 0036-0039
(2017/07/01)
-
- Solvent-free synthesis of 2,2'-methylene-bis[4-tert-octyl-6-(2H-benzotriazolyl-2)]phenol
-
The invention discloses a method for synthesizing 2,2'-methylene-bis[4-tert-octyl-6-(2H-benzotriazolyl-2)]phenol (UV-360) through solvent-free condensation. The method comprises the procedures of firstly, carrying out condensation dehydration on di-n-propyl amine and formaldehyde or paraformaldehyde, which serve as raw materials, at the temperature of about 120 DEG C so as to synthesize di(n-propylamino)methane, and then, carrying out condensation with 2-(2'-hydroxyl-5'-tert-octylphenyl)benzotriazole at the temperature of about 160 DEG C under the catalysis of sodium hydroxide under solvent-free conditions, thereby synthesizing the UV-360. According to the method, no high-boiling solvent is used, so that problems of the existing methods are solved; and di-n-propyl amine is easy to recover and recycle, and the product quality is high.
- -
-
Paragraph 0033; 0034; 0035; 0036; 0037-0049; 0052; 0053
(2017/08/29)
-
- Method for preparation of 2,2'-methylenebis[6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)phenol]
-
The invention discloses a method for preparation of 2,2'-methylenebis[6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethyl butyl)phenol]. The method comprises the steps: adding 2-(2-hydroxy-5-t-octyl)phenyl benzotriazole, an aromatic hydrocarbon solvent, secondary amine and paraformaldehyde into a reactor, heating up to 130-160 DEG C, carrying out a heat preservation dehydration reaction for 1-4 hours, adding a catalyst, dehydrating and heating up to 160-190 DEG C while heating, and carrying out heat preservation for 2-5 hours; and after the completion of the reaction, cooling the reaction liquid, neutralizing, carrying out alcohol precipitation, filtering, and drying to obtain UV-360. Compared with a conventional synthetic route, the yield of the product can reach more than or equal to 92%, and the maximum yield can reach more than or equal to 96%, so the production cost of the product is lower; the product has good quality, and the content of the product can reach more than or equal to 99.5%. Moreover, the operation process is simple and reliable, and the conditions are easy to control, so the method can meet demand of industrialized mass production.
- -
-
Paragraph 0027; 0028
(2016/11/07)
-
- COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT
-
The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group FA which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group FC capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group FA.
- -
-
-
- ALPHA-AMINO ACID DERIVATIVES FOR IMPROVING SOLUBILITY
-
The invention relates to the use of α-amino acid derivatives for improving the solubility of poorly soluble substances in water or aqueous solutions and to mixtures and preferred preparations.
- -
-
-
- Cosmetic compositions comprising photostabilized dibenzoylmethane compounds and 2-pyrrolidinone-4- carboxy esters
-
Photostable cosmetic compositions contain, formulated into a cosmetically acceptable vehicle, at least one UV-screening system that includes: (a) at least one dibenzoylmethane compound, and(b) at least one 2-pyrrolidinone-4-carboxy ester compound having the following formula (I): in which: R1 is a linear or branched C1-C20 alkyl radical, andR2 is a linear or branched C1-C20 alkyl radical which optionally includes a C5-C6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical.
- -
-
-
- Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
-
Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.
- -
-
-
- COSMETIC OIL-IN-WATER EMULSION
-
A cosmetic or dermatological compositions of oil-in-water emulsion type, including, in a physiologically acceptable medium, at least gemini surfactant of formula (I): in which R1 and R3 denote, independently of one another, an alkyl radical containing from 1 to 25 carbon atoms; R2 denotes a spacer consisting of a linear or branched alkylene chain containing from 1 to 12 carbon atoms; X and Y denote, independently of one another, a group —(C2H4O)a—(C3H6O)bZ; n ranges from 1 to 10, in combination with an effective amount of at least one semi-crystalline polymer which is solid at ambient temperature and which has a melting point below 70° C., said polymer having a number-average molecular mass greater than or equal to 2000, said emulsion having a proportion of fatty phase of greater than 10% by weight relative to the total weight of the composition and including more than 40% by weight of non-volatile oil(s) relative to the weight of the fatty phase.
- -
-
-
- USE OF FLAVONOIDS
-
The present invention relates to the use of at least one flavonoid for odour improvement and/or odour stabilisation, and to corresponding compositions and the preparation thereof.
- -
-
-
- Flavonoids as Synergists for Enhancing the Action of Self-Tanning Substances
-
The invention relates to the use of at least one flavonoid having an uncharged flavan skeleton as synergist for enhancing the action of self-tanning substances, such as trioses and tetroses, in cosmetic and dermatological formulations and to corresponding novel compositions and to the preparation thereof.
- -
-
-
- Photoprotective cosmetic compositions comprising photostabilized dibenzoylmethane compounds and siloxane-containing arylalkyl benzoate amide compounds
-
Photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane sunscreen compound and at least one photostabilizing siloxane-containing arylalkyl amide compound of formula (I) below:
- -
-
-
- Process for the preparation of benzotriazoles
-
A process for the preparation of compounds of formula (I): wherein the general symbols are as defined in claim 1, which comprises reacting a compound of formula (V): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R18 are as defined in claim 1, and R18 is especially nitro, chlorine or bromine, with an azide compound of formula (IX): wherein M and n are as defined in claim 1, especially with sodium azide.
- -
-
-
- LOW DUSTING CRYSTAL TRANSFORMATIONS OF 2, 2'-METHYLENBIS 4-(1,1,3,3-TETRAMETHYLBUTYL)-6-BENZOTRIAZOLYLPHENOL AND MIXTURE THEREOF, METHOD FOR PREPARING THEM, AND ULTRAVIOLET ABSORBENT USING THE SAME
-
The present invention relates to a low dusting crystalline 2,2'-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol) type I crystal transformation which exhibits diffraction peaks at diffraction angles (2θ± 0.1°) of 7.1°, 8.6°, 14.3°, 16.1°, 18.1° and 23.0° in powder X-ray diffraction analysis with Cu-Kα radiation; a low dusting 2,2'-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] type II crystal transformation which does not exhibit a distinct diffraction peak but an amorphous halo in powder X-ray diffraction analysis with Cu-Kα radiation; a mixture thereof; a method for preparing them; and a UV light absorber, an emulsion composition and a polymer material using them.
- -
-
-
- Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles
-
Nonaerosol/atomizer pumps or aerosol dispensers comprise (A) a reservoir confining at least one vaporizable sunscreen composition suited for UV-photoprotecting the skin and/or hair against the damaging effects of UV radiation, the at least one vaporizable sunscreen composition comprising (1) a UV-photoprotecting amount of at least one UV-sunscreen and (2) an SPF-enhancing amount of generally spherical silica microparticles, formulated into (3) a topically applicable, cosmetically acceptable carrier therefor, and (B) at least one agent for pressurizing the at least one vaporizable sunscreen composition into a spray of fine sunscreen particles.
- -
-
-
- Phase inverted oil-in-water photoprotective emulsions comprising nanopigments of metal oxides and 4,4-diarylbutadiene UV-A sunscreens
-
Stable UV-photoprotective, phase inverted oil-in-water emulsions, well suited for the photoprotection of the skin, lips and/or hair, the average size of the globules which constitute the oily phase thereof ranging from 100 nm to 1,000 nm, contain inorganic metal oxide nanopigments and at least one organic UV-screening agent, and which also contain at least one organic 4,4-diarylbutadiene UV-A-screening agent.
- -
-
-
- Aqueous photoprotective compositions comprising acrylamido-2-methylpropanesulfonic acid polymers and 4,4-diarylbutadiene UV-A sunscreens
-
Photoprotective compositions, e.g., oil-in-water or water-in-oil emulsions, well suited for the photoprotection of the skin, lips and/or hair against the damaging effects of UV-radiation, comprise at least one aqueous phase, at least one oily phase, at least one partially or completely neutralized, crosslinked or non-crosslinked water-soluble or water-dispersible acrylamido-2-methylpropanesulfonic acid (AMPS) polymer and at least one UV radiation-screening system, said at least one screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent
- -
-
-
- Water-in-oil photoprotective emulsions comprising polyolefinic surfactants and 4,4-diarylbutadiene UV-A sunscreens
-
Stable UV-photoprotective water-in-oil emulsions, well suited for the photoprotection of the skin, lips and/or hair against the damaging effects of UV-radiation, contain at least one polymeric surfactant comprising at least one polar part and at least one polyolefinic apolar part, and also containing at least one organic 4,4-diarylbutadiene UV-A-screening agent.
- -
-
-
- Finely divided photoprotective oil-in-water emulsions comprising 4,4-diarylbutadiene UV-A sunscreens
-
UV-Photoprotective oil-in-water emulsions well suited for photoprotecting the skin, lips and/or hair against the damaging effects of UV-radiation, the oil globules of which having an average size of at most 500 nm and containing particles of at least one ionic polymer and at least one UV-radiation-screening system, such screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent.
- -
-
-
- Low-emulsifier or emulsifier-free systems of the oil-in-water type with a content of stabilizers and an amino-substituted hydroxybenzophenone
-
Cosmetic or dermatological preparations which represent finely disperse systems of the oil-in-water type, comprising a) an oil phase, b) a water phase, c) one or more stabilizers, d) at most 2.00% by weight of one or more emulsifiers, and e) an amino-substituted hydroxybenzophenone of the formula I
- -
-
-
- Phosphites and their production and use
-
Phosphites represented by the general formula (I): STR1 wherein R1, R2, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkylcycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms or a phenyl group; R3 and R6 independently represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; X1 is a dihydric alcohol residue, wherein HO--X1 --OH defines the corresponding dihydric alcohol from which residue X1, is obtained; and X2 is a direct bond or an alkylene group having 1 to 8 carbon atoms; and the phosphites are useful as stabilizers for organic materials.
- -
-
-
- Piperidine compound, a process for producing the same and a stabilizer using the same
-
2-Methyl-3-(2,2,6,6-tetramethyl-4-piperidylamino)-N-(2,2,6,6-tetramethyl-4-piperidyl)-propionamide represented by the following formula, a process for producing the same and a stabilized organic material composition containing the same wherein the piperidine compound imparts excellent properties, such as light stability or thermal stability to the organic materials. STR1
- -
-
-
