- OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE
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Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.
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Page/Page column 171
(2019/06/05)
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- Stereoretentive Intramolecular Glycosyl Cross-Coupling: Development, Scope, and Kinetic Isotope Effect Study
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A series of cyclic C-glycosides were synthesized using the palladium-catalyzed stereoretentive intramolecular glycosylation of aryl iodides by employing a bulky phosphine ligand. A variety of functional groups are tolerated in the reaction, and enantioenr
- Yi, Duk,Zhu, Feng,Walczak, Maciej A.
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supporting information
p. 4627 - 4631
(2018/08/07)
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- DIFLUOROMETHYLENE COMPOUND
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The present invention relates to a compound having an URAT1 inhibitory activity, and to an URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition containing the compound. More specifically, the present invention relates to a compound represented by the formula (I): wherein R1 is -Q1-A1 or the like; R2 is a hydrogen atom, a halogen atom, a lower alkyl group or the like; W1, W2, W3 and W4 are each independently a nitrogen atom or a methine group optionally having substituents, or the like; X and Y are each a single bond, an oxygen atom or the like; Z is a hydroxyl group or COOR3 or the like.
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Paragraph 0404; 0405; 0897; 0898
(2015/06/16)
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- A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists
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The synthesis of a series of chiral indanes with reported α1A partial agonist activity is outlined, applying a rhodium catalysed cyclisation for template construction. This method was extended to the asymmetric synthesis of lead compound PF-037
- Roberts, Lee R.,Corbett, Matthew S.,Fussell, Steven J.,Hitzel, Laure,Jessiman, Alan S.,Mason, Helen J.,Osborne, Rachel,Ralph, Michael J.,Stennett, Adam S.D.,Wheeler, Simon,Storer, R. Ian
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supporting information
p. 6546 - 6550
(2015/11/09)
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- Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists
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A novel series of central nervous system (CNS) penetrant indane 2-imidazoles have been identified as potent, partial agonists of the α1A adrenergic receptor, having good selectivity over the α1B, α1D and α2 sub-
- Roberts, Lee R.,Bryans, Justin,Conlon, Kelly,McMurray, Gordon,Stobie, Alan,Whitlock, Gavin A.
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scheme or table
p. 6437 - 6440
(2009/10/01)
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- Synthesis and Structure of 1,7-Dichlorodibenzoheptalene-4,10-dione, a Saddle-Shaped Polycyclic Aromatic Compound
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We describe the synthesis and X-ray crystal structure of the title compound, which is the first fully unsaturated derivative of dibenzoheptalene to be prepared.The X-ray structure reveals a saddle-shaped molecule possessing approximate C2/sub
- Pascal, Robert A.,Ho, Douglas M.
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