A new paradigm for biohydroxylation by Beauveria bassiana ATCC 7159
The biohydroxylation of a series of amides and related amino, keto and hydrocarbon substrates by the fungal biocatalyst Beauveria bassiana ATCC 7159 has been examined. The product distributions, together with data obtained from selective inhibition experiments using the cyt.P-450 inhibitors isosafrole, 1-aminobenzotriazole and phenylacetylene, suggest that B. bassiana contains a range of hydroxylase enzymes with different substrate specificities. A paradigm is presented for the interpretation of the results of microbial hydroxylation and for the application of existing active site models for B. bassiana.
Holland, Herbert L.,Morris, Terence A.,Nava, Phillip J.,Zabic, Mirjana
p. 7441 - 7460
(2007/10/03)
Biooxidations of some N-Arylpiperidines and Related Compounds using Beauveria sulfurescens
Beauveria sulfurescens ATCC 7159 oxidized the N-arylamines 3, 4, 7, 13, 18, 20, 22 at the 4-position with good selectivity and in 34 - 66percent yield.
Floyd, Nicholas,Munyemana, Francois,Roberts, Stanley M.,Willetts, Andrew J.
p. 881 - 882
(2007/10/02)
Selective Oxygenation of Adamantanes and Other Substrates by Beauveria sulfurescens
Oxygenation of N-(2-adamantyl)benzamide (7) with the fungus Beauveria sulfurescens (ATCC 7159) gave 4β-benzamidoadamantan-1-ol (8), whose structure was determined by X-ray crystallography.Oxygenation of N-methyl-N-(4-methyleneadamant-1-yl)benzamide (9) gave two products, the β-epoxide 10 and the 5-hydroxy β-epoxide 11, the latter structure determined by X-ray crystallography.Oxygenation of 4-methylene-1-(p-toluenesulfonyl)piperidne (12) gave 4-hydroxy-4-(hydroxymethyl)-1-(p-toluenesulfonyl)piperidine (14) and of 4-piperidinoacetophenone (13) gave 4-(4-hydroxypiperidino)acetophenone (15).
Johnson, Roy A.,Herr, Milton E.,Murray, Herbert C.,Chidester, Constance G.,Han, Fusen
p. 7209 - 7212
(2007/10/02)
A Convenient Synthesis of 1-Aryl-4-piperidones
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Taylor, Edward C.,Skotnicki, Jerauld S.
p. 606 - 608
(2007/10/02)
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