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2,3-Pyrazinecarboxylic anhydride

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Name

2,3-Pyrazinecarboxylic anhydride

EINECS 225-260-4
CAS No. 4744-50-7 Density 1.686 g/cm3
PSA 69.15000 LogP -0.21280
Solubility N/A Melting Point 210 °C (dec.)(lit.)
Formula C6H2N2O3 Boiling Point 357.3 °C at 760 mmHg
Molecular Weight 150.093 Flash Point 169.9 °C
Transport Information N/A Appearance white of off-white power
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 4744-50-7 (2,3-Pyrazinecarboxylic anhydride) Hazard Symbols IrritantXi
Synonyms

2,3-Pyrazinedicarboxylicanhydride (6CI,7CI,8CI);2,3-Pyrazinedicarboxylic acid anhydride;Furano[3,4-b]pyrazine-5,7-dione;

Article Data 15

2,3-Pyrazinecarboxylic anhydride Synthetic route

89-01-0

2,3-dicarboxypyrazine

4744-50-7

2,3-pyrazinedicarboxylic anhydride

Conditions
ConditionsYield
With acetic anhydride for 0.0833333h;94%
With acetic anhydride Heating;93%
With acetic anhydride for 0.166667h; Heating;83%
89-01-0

2,3-dicarboxypyrazine

108-24-7

acetic anhydride

4744-50-7

2,3-pyrazinedicarboxylic anhydride

Conditions
ConditionsYield
for 1h; Reflux;70%
91-19-0

2,3-diethynylquinoxaline

4744-50-7

2,3-pyrazinedicarboxylic anhydride

Conditions
ConditionsYield
(i) KMnO4, (ii) Ac2O; Multistep reaction;
67-56-1

methanol

4744-50-7

2,3-pyrazinedicarboxylic anhydride

73763-86-7

3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid

Conditions
ConditionsYield
for 12h; Ambient temperature;100%
at 20℃; for 72h;75%
60-35-5

acetamide

4744-50-7

2,3-pyrazinedicarboxylic anhydride

135742-53-9

N-acetylpyrazine-2-carboxamide

Conditions
ConditionsYield
for 4h; Reflux;100%
1072-98-6

5-chloro-2-pyridylamine

4744-50-7

2,3-pyrazinedicarboxylic anhydride

43200-83-5

3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;99%
In tetrahydrofuran at 20℃; for 1h;99%
In dichloromethane at 5 - 20℃; for 3.5h; Product distribution / selectivity;
Stage #1: 5-chloro-2-pyridylamine; 2,3-pyrazinedicarboxylic anhydride In toluene at 20 - 52℃; for 2.5h;
Stage #2: With hydrogenchloride In water at 10 - 15℃; for 1h;
4744-50-7

2,3-pyrazinedicarboxylic anhydride

265332-93-2

4-amino-2,5-dimethoxy-N-phenylbenzamide

1454692-94-4

N-(2,5-dimethoxy-4-(phenylcarbamoyl)phenyl)pyrazine-2-carboxamide

Conditions
ConditionsYield
In toluene for 12h; Inert atmosphere; Reflux;99%
4744-50-7

2,3-pyrazinedicarboxylic anhydride

768-94-5

1-Adamantanamine

405081-00-7

N-((3s,5s,7s)-adamantan-1-yl)pyrazine-2-carboxamide

Conditions
ConditionsYield
In toluene for 12h; Inert atmosphere; Reflux;99%
4744-50-7

2,3-pyrazinedicarboxylic anhydride

62-53-3

aniline

34067-83-9

N-(phenyl)pyrazine-2-carboxamide

Conditions
ConditionsYield
In toluene for 12h; Inert atmosphere; Reflux;99%
61-54-1

tryptamine

4744-50-7

2,3-pyrazinedicarboxylic anhydride

733761-59-6

C16H14N4O3

Conditions
ConditionsYield
In dichloromethane at 20℃; for 18h;98%

2,3-Pyrazinecarboxylic anhydride Specification

The Furo[3,4-b]pyrazine-5,7-dione, with CAS registry number 4744-50-7, belongs to the following product categories: (1)Glycinescaffold; (2)Fused Ring Systems. It has the systematic name of furo[3,4-b]pyrazine-5,7-dione. And the chemical formula of this chemical is C6H2N2O3. What's more, its EINECS is 225-260-4.

Physical properties of Furo[3,4-b]pyrazine-5,7-dione: (1)ACD/LogP: -0.90; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.9; (4)ACD/LogD (pH 7.4): -0.9; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 7.74; (8)ACD/KOC (pH 7.4): 7.74; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 69.15 Å2; (13)Index of Refraction: 1.634; (14)Molar Refractivity: 31.86 cm3; (15)Molar Volume: 89 cm3; (16)Polarizability: 12.63×10-24cm3; (17)Surface Tension: 90 dyne/cm; (18)Density: 1.686 g/cm3; (19)Flash Point: 169.9 °C; (20)Enthalpy of Vaporization: 60.26 kJ/mol; (21)Boiling Point: 357.3 °C at 760 mmHg; (22)Vapour Pressure: 2.76E-05 mmHg at 25°C.

Preparation: this chemical can be prepared by pyrazine-2,3-dicarboxylic acid. This reaction will need reagent thionyl chloride.

When you are using this chemical, please be cautious about it as the following:
The Furo[3,4-b]pyrazine-5,7-dione irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C1OC(=O)c2nccnc12
(2)InChI: InChI=1/C6H2N2O3/c9-5-3-4(6(10)11-5)8-2-1-7-3/h1-2H
(3)InChIKey: AWJWCTOOIBYHON-UHFFFAOYAK
(4)Std. InChI: InChI=1S/C6H2N2O3/c9-5-3-4(6(10)11-5)8-2-1-7-3/h1-2H
(5)Std. InChIKey: AWJWCTOOIBYHON-UHFFFAOYSA-N

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