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Cas Database |
| Name |
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one |
EINECS | 1308068-626-2 |
| CAS No. | 196597-78-1 | Density | 1.289 g/cm3 |
| PSA | 26.30000 | LogP | 1.75040 |
| Solubility | N/A | Melting Point |
149-151 °C |
| Formula | C11H10O2 | Boiling Point | 334.156 °C at 760 mmHg |
| Molecular Weight | 174.199 | Flash Point | 165.595 °C |
| Transport Information | N/A | Appearance | White solid |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
6,7-Dihydro-1H-indeno[5,4-b]furan-8(2H)-one; |
Article Data | 20 |
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Synthetic route
- 1205098-83-4
1-(2,3-dihydrobenzofuran-4-yl)-2-propen-1-one
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| With copper(II) bis(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 10 - 20℃; for 16h; Solvent; Reagent/catalyst; | 96.3% |
| With sulfuric acid In pentane at 67℃; Product distribution / selectivity; Inert atmosphere; | |
| With sulfuric acid In water; pentane at 67℃; for 0.5h; Inert atmosphere; |
- 196597-77-0
4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; acetic acid; 10percent Pd/C/H2O at 20℃; for 1h; | 89% |
| With hydrogen; sodium acetate; 5% palladium over charcoal In water; acetic acid at 20℃; | 89% |
| With hydrogen; sodium acetate; palladium 10% on activated carbon In methanol at 40℃; under 2175.22 - 3675.37 Torr; for 8h; | 88.6% |
- 196597-77-0
4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
A
- 1092507-06-6
C11H12O
B
- 1092507-07-7
2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ol
C
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; sodium acetate; acetic acid; palladium 10% on activated carbon under 1471.14 - 2206.72 Torr; | A n/a B n/a C 85% |
- 15480-25-8
6,7-dihydro-8H-indeno-[5,4-b]furan-8-one
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; 5% Pd(II)/C(eggshell); triethylamine In tetrahydrofuran; ethanol at 35℃; under 4500.45 - 5250.53 Torr; for 24h; | 62% |
- 1198465-69-8
4-tert-butyl-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride; aluminum (III) chloride In benzene | 20% |
- 496-16-2
2,3-Dihydrobenzofuran
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1.1: 92 percent / TiCl4 / CH2Cl2 / 1 h 2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C 2.2: 88 percent / tetrahydrofuran / 1 h / 20 °C 3.1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C 4.1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C 5.1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C 6.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 7.1: SOCl2 / 75 °C 8.1: AlCl3 / 1,2-dichloro-ethane / 20 °C 9.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C View Scheme | |
| Multi-step reaction with 9 steps 1.1: 86 percent / POCl3 / 12 h / 80 - 85 °C 2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C 2.2: 88 percent / tetrahydrofuran / 1 h / 20 °C 3.1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C 4.1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C 5.1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C 6.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 7.1: SOCl2 / 75 °C 8.1: AlCl3 / 1,2-dichloro-ethane / 20 °C 9.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C View Scheme | |
| Multi-step reaction with 6 steps 1.1: trichlorophosphate / 5.17 h / 30 - 98 °C 2.1: sodium methylate / toluene / 0.25 h / 0 - 30 °C 3.1: hydrogen / nickel / methanol / 4 h / 50 °C 4.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C 5.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C 5.2: 1 h / -5 - 5 °C 6.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C View Scheme |
- 55745-70-5
2,3-dihydro-benzofuran-5-carbaldehyde
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: NaH / tetrahydrofuran / 0.33 h / 20 °C 1.2: 88 percent / tetrahydrofuran / 1 h / 20 °C 2.1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C 3.1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C 4.1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C 5.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 6.1: SOCl2 / 75 °C 7.1: AlCl3 / 1,2-dichloro-ethane / 20 °C 8.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C View Scheme | |
| Multi-step reaction with 5 steps 1.1: sodium methylate / toluene / 0.25 h / 0 - 30 °C 2.1: hydrogen / nickel / methanol / 4 h / 50 °C 3.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C 4.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C 4.2: 1 h / -5 - 5 °C 5.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C View Scheme | |
| Multi-step reaction with 6 steps 1.1: piperidine; pyridine / 6 h / 120 °C 2.1: thionyl chloride / 0.67 h / 26 - 73 °C / Heating / reflux 3.1: hydrogen / nickel / methanol / 4 h / 50 °C 4.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C 5.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C 5.2: 1 h / -5 - 5 °C 6.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C View Scheme | |
| Multi-step reaction with 5 steps 1.1: piperidine; pyridine; acetic acid / 4 - 5 h / 100 °C 1.2: 2 - 3 h / 20 °C 2.1: sodium hydroxide; hydrogen; ammonium formate / palladium 10% on activated carbon / water / 5 - 6 h / 20 °C 3.1: bromine; sodium acetate; acetic acid / 2 - 3 h / 0 - 45 °C 4.1: thionyl chloride / N,N-dimethyl-formamide / 1 - 2 h / 20 °C 4.2: 1 - 2 h / 0 - 5 °C 5.1: hydrogen; sodium acetate; acetic acid / palladium 10% on activated carbon / 1471.14 - 2206.72 Torr View Scheme | |
| Multi-step reaction with 6 steps 1: sodium t-butanolate / toluene / 1 h 2: acetic acid; hydrogen; 5%-palladium/activated carbon / 1 h / 50 °C / 1470.15 - 2205.22 Torr 3: acetic acid; sodium acetate; bromine / 6 h / 20 °C / Cooling 4: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C 5: aluminum (III) chloride / 0.5 h / Cooling with ice 6: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr View Scheme |
- 196597-65-6
ethyl (E)-3-(2,3-dihydrobenzofuran-5-yl)-2-propenoate
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C 2: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C 3: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C 4: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 5: SOCl2 / 75 °C 6: AlCl3 / 1,2-dichloro-ethane / 20 °C 7: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C View Scheme | |
| Multi-step reaction with 5 steps 1: acetic acid; hydrogen; 5%-palladium/activated carbon / 1 h / 50 °C / 1470.15 - 2205.22 Torr 2: acetic acid; sodium acetate; bromine / 6 h / 20 °C / Cooling 3: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C 4: aluminum (III) chloride / 0.5 h / Cooling with ice 5: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr View Scheme |
- 196597-66-7
ethyl 3-(2,3-dihydro-1-benzofuran-5-yl)propanoate
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C 2: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C 3: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 4: SOCl2 / 75 °C 5: AlCl3 / 1,2-dichloro-ethane / 20 °C 6: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C 2.2: 1 h / -5 - 5 °C 3.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C View Scheme | |
| Multi-step reaction with 4 steps 1: acetic acid; sodium acetate; bromine / 6 h / 20 °C / Cooling 2: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C 3: aluminum (III) chloride / 0.5 h / Cooling with ice 4: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr View Scheme |
- 196597-67-8
ethyl 3-(7-bromo-2,3-dihydro-1-benzofuran-5-yl)propanoate
- 196597-78-1
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C 2: 93 percent / aq. KOH / ethanol / 1 h / 90 °C 3: SOCl2 / 75 °C 4: AlCl3 / 1,2-dichloro-ethane / 20 °C 5: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C View Scheme |
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Chemical Properties
The Molecular Structure of 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one (CAS NO.196597-78-1):
Empirical Formula: C11H10O2
Molecular Weight: 174.1959
Nominal Mass: 174 Da
Average Mass: 174.1959 Da
Monoisotopic Mass: 174.06808 Da
Index of Refraction: 1.624
Molar Refractivity: 47.726 cm3
Molar Volume: 135.156 cm3
Surface Tension: 53.251 dyne/cm
Density: 1.289 g/cm3
Flash Point: 165.595 °C
Enthalpy of Vaporization: 57.709 kJ/mol
Boiling Point: 334.156 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Product Categories: Aromatics Compounds;Aromatics;Heterocycles
Appearance: White Solid
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Uses
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one (CAS NO.196597-78-1) can be used as receptor agonist and a therapeutic agent for sleep disorders.
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Specification
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one (CAS NO.196597-78-1) is also called as 1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one .
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1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
